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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

1. A research laboratory is investigating the mechanisms of antigenic variation in Trypanosoma brucei, the causative agent of African trypanosomiasis. The parasite evades the host immune response by periodically changing its surface coat protein. This process primarily involves:

A) High-frequency point mutations in the gene encoding the variant surface glycoprotein (VSG).
B) Segmental gene conversion events involving a large repertoire of silent VSG genes.
C) RNA interference-mediated silencing of expressed VSG genes followed by activation of a new VSG gene.
D) Recombination between different VSG gene loci on minichromosomes.

2. A clinical microbiology laboratory is implementing a new quality control procedure for blood culture media.
To ensure the media supports the growth of a wide range of clinically significant organisms, they should include:

A) Only antibiotic-resistant control strains.
B) Only Gram-positive and Gram-negative control strains.
C) A diverse panel of fastidious and non-fastidious bacteria and yeasts.
D) Only control strains that are commonly found as contaminants.

3. A patient with a history of travel to a developing country presents with chronic diarrhea, abdominal pain, and weight loss. Stool examination reveals the presence of cysts containing four nuclei and chromatoidal bars with rounded ends. The MOST likely causative organism is:

A) Cyclospora cayetanensis
B) Cryptosporidium parvum
C) Entamoeba histolytica
D) Giardia lamblia

4. A microbiology laboratory is performing Gram staining on a bacterial smear. If the safranin counterstain is omitted, Gram-negative bacteria will appear:

A) Blue
B) Colorless
C) Purple
D) Brown

5. A laboratory worker sustains a needlestick injury while handling a blood sample known to be positive for Hepatitis B surface antigen (HBsAg) and Hepatitis B e antigen (HBeAg). The worker has completed the HBV vaccination series and has a documented anti-HBs titer >10 mIU/mL one month ago. What is the recommended post-exposure prophylaxis?

A) No treatment required
B) Both HBIG and HBV vaccine booster dose
C) Hepatitis B vaccine booster dose only
D) Hepatitis B immune globulin (HBIG) only

Solutions: